Of the 14 Inter conference games in 1965, the East won just one game. In mid-season, the Dallas Cowboys defeated the San Francisco Forty-Niners 39 to 31. San Francisco gained 411 yards to just 242 yards for the Cowboys. It was a combination of big defensive plays and special teams. Dallas had only nine first downs.
For San Francisco-George Mira completed 14 of 30 passes for 274 yards with two touchdowns and two interceptions. Ken Willard carried 25 times for 91 yards. Dave Parks caught six passes for 120 yards and two touchdowns.
For Dallas-Don Meredith completed 11 of 20 passes for 216 yards two touchdowns and two interceptions. Bob Hayes caught four passes for 108 yards and two touchdowns. There were the following:
—Defensive Tackle Bob Lilley intercepted one pass and returned it 17 yards for a touchdown.
—Mel Renfro returned a kickoff 100 yards for a touchdown.
—George Andre recovered a fumble in the End Zone for a touchdown.
Cowboys 39 49ers 31.